Spinal Nerve Ligation in Mouse Upregulates TRPV1 Heat Function in Injured IB4-Positive Nociceptors
نویسندگان
چکیده
منابع مشابه
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses.
Vanilloid receptor 1 (TRPV1) has been proposed to be the principal heat-responsive channel for nociceptive neurons. The skin of both rat and mouse receives major projections from primary sensory afferents that bind the plant lectin isolectin B4 (IB4). The majority of IB4-positive neurons are known to be heat-responsive nociceptors. Previous studies suggested that, unlike rat, mouse IB4-positive...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2010
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2009.09.018